11/21/18 MicroRNAs as therapeutic agents
11/24/18 at 8:14 AM from Nature Research (Nature@newsletter.nature.com)
“Optogenetics is a method that uses light to modulate molecular events in a targeted manner in living cells or organisms. Research by leading labs in the field, including those of Breakthrough Prize winners, is presented in this free-to-access collection of articles from Scientific Reports.”
Biophotonic energy as information and biophysically constrained optogenetic RNA interference link light-activatated microRNA biogenesis to microRNA-mediated prevention and/or effective treatment of all pathology. The virus-driven degradation of messenger RNA must be prevented by food energy the context of biophysically constrained transgenerational epigenetic inheritance.
Nature Research began to fall decades behind after McEwen et al., (1964) linked the creation of ATP to the creation of RNA.
The synthesis of RNA in isolated thymus nuclei is ATP dependent.
…photoexcited DNA leads to reactive charge transfer states.
More likely it is the driving power represented by the oxidation potential of the radical ion, which controls the repair. Thus, repair capacities are strongly sequence-dependent, creating DNA regions with different tendencies of self-repair. This self-healing activity represents the simplest sequence-dependent DNA repair system.
Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy. The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements.
The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection. This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA.
Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes. For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.