Detailed differences in energy-dependent signaling networks linked ~96,000 publications on microRNAs from my refutation of neo-Darwinian pseudoscientific nonsense: Nutrient-dependent/pheromone-controlled adaptive evolution: a model 6/14/13 to MicroRNA-based regulation of [biophysically constrained] epithelial–hybrid–mesenchymal fate determination 11/5/13. That was more than 6 years ago.
Since then, the energy-dependent biophysical constraints on the signalling networks have been linked to the patented cure for all cancers.
See also their “Proof of concept”
For a current summary of what is known to all intelligent serious scientists about biophysically constrained viral latency and healthy longevity, see:
Molecular mechanisms of epithelial to mesenchymal transition in tumor metastasis 12/28/19
…describes different signaling networks between microRNAs and proteins that regulate [biophysically constrained] EMT in tumor growth.
For a historical perspective on biophysically constrained scientific truths, see: Bacterial self-organization: co-enhancement of complexification and adaptability in a dynamic environment 5/7/2003 and Learning from Bacteria about Natural Information Processing 10/15/2009
The author of both those monographs is the late Eshel Ben-Jacob, who was a member of The International Paleopsychology Project in the late 1990’s. Science fiction author Greg Bear was a member, and so was I.
Greg Bear took Eshel Ben-Jacob’s claims and my claims about the food energy-dependent pheromone-controlled physiology of reproduction and linked them from natural information processing and pheromone-constrained quorum-sensing in bacteria to the creation of an advanced group of humans in one generation of biophysically constrained virus-driven ecological adaptations.
See the reviews of Darwin’s Radio (1999) and Darwin’s Children (2003).
Evolution rising from the grave (2000)
It portrays scientists as real people, responding to the intense politics of the biomedical world, the funding imperative in public and private sector alike, and the terrifying challenge of a disease that threatens to decimate the human species. It takes a hard look at the challenges faced by a woman scientist with radical ideas, and the excitement of discovering a totally new way of looking at biological evolution.
Living with the Neanderthals (2003)
Like all the best science fiction, Darwin’s Children is a medium for telling the public about science. Through one of his characters, Bear pleads for biologists to write clearly: “Don’t they realize how important it is to get the word out to everybody?”
Compare everything that all intelligent serious scientists have learned about energy-dependent biophysically constrained viral latency to ridiculous, but clear, claims from Mutation-Driven Evolution 6/14/13 and to this example of human idiocy Criticisms of the nutrient-dependent pheromone-controlled evolutionary model 6/4/14
1) …splicing does not have the capability to make changes to the genome itself. He explicitly denies the contribution of mutations to genotypic and phenotypic variety, claiming that ‘biophysical constraints’ prevent ‘constraint-breaking mutations’ (phrases taken from Nei, 2013) from being involved in evolution entirely (Kohl, 2014a). Mutations are, according to him, only involved in disease and cannot result in adaptive traits, despite the massive amount of evidence contrary to that.
2) Allele changes are not epigenetic and I know of no mechanism that makes deterministic gene sequence changes prompted by epigenetic alterations. A multitude of misconceptions and misunderstandings can be seen in his comments on Dr. PZ Myers’ blog, Pharyngula (Kohl, 2014b). For example, in comment #125, Kohl says that proteasomes mediate protein folding. Proteasomes do no such thing. They are actually structures whose function is to break down proteins.
Here is the problem with attempts to write clearly when the target audience turns out to be a group of biologically uninformed science idiots. Andrew Jones, PZ Myers, and the idiot minions of atheists, do not seem to know that Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases.
Even a Wiki-idiot could learn to start with the energy-dependent creation of enzymes and this: The degradation process yields peptides of about seven to eight amino acids long, which can then be further degraded into shorter amino acid sequences and used in synthesizing new proteins.[1]
See also: Targeting miRNAs by polyphenols: Novel therapeutic strategy for aging 11/1/19
Polyphenols as important antioxidants in human dietary observed in fruits and some beverages have beneficial effects on longevity and aging. Considering miRNAs as an interesting mediator in modulating polyphenols′ biological effects, targeting miRNAs which is using polyphenols could be a novel strategy for aging.
Q: Who does not want others to link what organisms eat to their physiology of reproduction and healthy longevity?
A: Theorists.
See also: Recent developments on polyphenol–protein interactions: effects on tea and coffee taste, antioxidant properties and the digestive system 6/1/12
Polyphenols can interact with proteins through hydrophobic or hydrophilic interactions, leading to the formation of soluble or insoluble complexes. According to recent studies, this complex formation can affect the bioavailability and beneficiary properties of both the individual components, in either way.
Supercoiled DNA is hydrophobic. Food and water must be linked from the Creation of sunlight to biophysically constrained viral latency by energy-dependent changes in base pairs, not by mutations and evolution.
See: MicroRNA and autophagy Items 1-1429
See also: Structural diversity of supercoiled DNA 10/12/15 and the ridicule of all theorists:
See also, other Food & Function articles
For a powerful summary statement the nearly all intelligent people can understand, see:
Remember, the synthesis of new proteins is light-activated and food energy-dependent. Light-activated microRNA biogenesis links the epigenetic effects of food to microRNA-mediated hydrophobic or hydrophilic interactions among proteins and supercoiled DNA. The interactions link what organisms eat from the metabolism of food to the pheromone-controlled physiology of reproduction, which biophysically constrains viral latency in species from microbes to humans.
The effects of anti-entropic virucidal light were linked from Schrodinger’s claims in What is Life? (1944) to the ATP-dependent creation of RNA-mediated cell type differentiation in 1964.
The synthesis of RNA in isolated thymus nuclei is ATP dependent.
Q: What caused the confusion that has remained during the past 55 years?
A: Theorists.
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.