10,000 reasons to believe in biophysical constraints (2)

If you are going to , you may need an update on what is known to all serious scientists. For example, compared to theorists, serious scientists know how ecological variation must link food odors and pheromones from jumping genes and transposons in bacteria to biophysically constrained ecological adaptations in vertebrates. In all vertebrates with jaws natural selection for energy-dependent codon optimality must be linked from microRNA biogenesis to biophysically constrained viral latency by RNA-mediated DNA repair.

Do not start to use your itinerary planner until you see: Molecular, spatial and functional single-cell profiling of the hypothalamic preoptic region 11/1/18

The hypothalamus controls essential social behaviors and homeostatic functions.

A mechanistic understanding of brain function requires a systematic assessment of cell types and their spatial organization, connectivity, and functional properties.

Cell type differentiation is energy-dependent. The energy comes from sunlight. Ages 10+ can learn how to link Subatomic particles to biophysically constrained viral latency via Cytosis.

If you have not yet learned how to link energy-dependent changes from angstroms to ecosystems in all living genera see:

Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems

To avoid embarrassment among your so-called peers, see for comparison: Evolution of Constrained Gonadotropin-releasing Hormone Ligand Conformation and Receptor Selectivity

…substitution of glycine for a chiral amino acid in GnRH during evolution allows a more constrained conformation for receptor binding and that this subtle single amino acid substitution in a site remote from the ligand functional domains has marked effects on its structure and activity.

10,000 neurons link what organisms eat to the physiology of reproduction via the biophysically constrained hypothalamic secretion of gonadotropin releasing hormone (GnRH) in all vertebrates with jaws. That fact allows for a significant comparison to ridiculous theories about mutations and evolution. Simply put, microRNAs, RNA, DNA, amino acid substitutions, proteins, and supercoiled DNA do not evolve.

See for review: Feedback loops link odor and pheromone signaling with reproduction (2005)

At least 10,000 neurons in 26 different brain areas appear to transmit signals directly to GnRH neurons. Among these are areas involved in odor and pheromone processing, sexual behavior, arousal, reward, and other functions. This suggests that GnRH neurons are poised to modulate reproductive physiology and behavior in accordance with the overall state of the animal.

These studies also indicate that GnRH neurons are likely to influence numerous brain functions. They appear to transmit signals to as many as 30,000 or more neurons in 34 brain areas, consistent with previous studies showing GnRH+ fibers and GnRH receptors in multiple brain regions. BL+ neurons likely to receive synaptic input from GnRH neurons were seen in areas associated with numerous different functions, including odor and pheromone processing, sexual behavior, appetite, defensive behavior, motor programs, and the relay of information to higher cortical areas. These results may reflect a strategy wherein GnRH neurons can modify diverse functions in order to coordinate the internal state of the animal and its behavior with reproduction in order to optimize reproductive success.

See also: Olfactory inputs to hypothalamic neurons controlling reproduction and fertility (2005)

The Nature of Olfactory Afferents to LHRH [GnRH] Neurons

Remarkably, our tracing experiments identify a small population of olfactory sensory neurons located in a medial zone of the olfactory mucosa as the major conduit of pheromonal cues that regulate LHRH synthesis and release. This neuronal subset may in part overlap with olfactory neurons shown to respond to volatile components of urine.

It is therefore likely that a dedicated population of olfactory receptors acts as genuine pheromone receptors, a result particularly interesting to consider in the context of animal species thought to be devoid of a functional vomeronasal system but displaying intriguing pheromonal-like responses. It has been reported for example that human axillary cues affect the timing of ovulation in women and the pulsatility of LHRH release, providing support to the idea that the pathway identified in our study may also operate in other species.

See also: The Scent of Eros: Mysteries of Odor in Human Sexuality (1995/2002)

Scientists have long known that chemical communication via pheromones is a powerful influence on how animals develop, mate, bond, and nurture their offspring. Human animals are no exception. Pheromones, explain the authors, alter hormone levels, can accelerate puberty, control women’s menstrual cycles, influence our choice in a mate, and even influence our sexual orientation.

The link from the anti-entropic virucidal energy of sunlight to the feedback loops that link epigenetic effects of food growth and food odors to the pheromones that biophysically constrained viral latency and all biodiversity was established in the early 1990s by the works of the late Robert L. Moss.  He clarified to me that LHRH and GnRH are the same hormone, something that was not always obvious in the extant literature until 2005, and even later. Finally, however, it became obvious to George Church et. al., who patented naturally occurring food energy-dependent pheromone-controlled RNA interference. See: RNA-Guided Human Genome Engineering

Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).

Robert L. Moss began to show others, like me, how to link biophysically constrained gene activation in GnRH neurosecretory neurons to viral latency and to human sexuality and all biodiversity in the early 1990s.

See: Moss RL GnRH Items: 1 to 20 of 47 and Gonadotropin releasing hormone [GnRH] and human sexual behavior (1991) in Neuropeptides and Psychiatric Disorders.

See also: Pheromones (2010) from Stress Science: Neuroendocrinology (This is a revised version of the article by C A Dudley, A Kumar and R L Moss, Encyclopedia of Stress, First edition, volume) 3.

Unfortunately, even now, biologically uninformed theorists continue to focus on the sequencing of the genetic code as if nothing had been learned about how food energy-dependent  pheromone-controlled gene activation must be linked from sunlight to microRNA biogenesis and biophysically constrained viral latency, which links light-activated microRNA biogenesis to energy-dependent RNA-mediated DNA repair in all living genera.

For a trip back in time, and evidence of overwhelming pervasive ignorance, see: Genetic code of 66,000 UK species to be sequenced 11/1/18

Sequencing the eukaryotic species in the UK and worldwide will revolutionise our understanding of biology and evolution, bolster efforts to conserve, help protect and restore biodiversity, and in return create new benefits for society and human welfare.

Sequencing the genetic code in more speceis can only prove that gene-centric theorists are biologically uninformed science idiots who think their ridiculous mathematical models are useful in the context of explanations for energy-dependent top-down causation via gene activation.

See for comparison: Mobile DNA Editor’s picks “Check out our monthly Editor’s Picks for #transposon research!” https://twitter.com/MobDNAjournal/status/1058285116827537408

The twitter feed announcement helps to call attention to Barbara McClintock’s works (the cytogeneticist who was awarded the 1983 Nobel Prize in Physiology or Medicine). Her works are readily linked to Rosalind Franklin’s works on the tobacco mosaic virus, and to Eugene Daev’s works on Pheromonal Regulation of Genetic Processes: Research on the House Mouse (Mus musculus L.) for comparison to how supercoiled DNA biophysically constrains viral latency in all living genera.

If you know you are on the right track, if you have this inner knowledge, then nobody can turn you off… no matter what they say. — Barbara McClintock

The specificity of pheromonal regulation… defines the reproductive status of individuals and, possibly, not only the quantity, but also the quality, of the progeny. — Eugene Daev

Ecological adaptation occurs via the epigenetic effects of nutrients on alternative splicings of pre-mRNA which result in amino acid substitutions that differentiate all cell types of all individuals of all species. The control of the differences in cell types occurs via the metabolism of the nutrients to chemical signals that control the physiology of reproduction. — James V. Kohl

See for comparison: One crank dies, another rises to take his place

According to PZ Myers and his idiot minions, I am the crank.

The success of biologically uninformed science idiots (neo-Darwinian theorists), like PZ Myers during the past few decades is amazing. Apparently, all that is required is their continued displays of human idiocy for comparison to:

 

See for comparison: Pity Jordan Peterson. Can a giant lobster analogy ever replace a sense of humour?

Summary: He is ridiculed for linking the food energy-dependent physiology of pheromone-controlled reproduction in crustaceans to all biophysically constrained biodiversity on Earth.

See: Role of olfaction in Octopus vulgaris reproduction (2015)

From the concluding paragraph: Future work on O. vulgaris olfaction must also consider how animals acquire the odours detected by the olfactory organ and what kind of odour the olfactory organ perceives. The OL acting as control centre may be target organ for metabolic hormones such as leptin like and insulin like peptides, and olfactory organ could exert regulatory action on the OL via epigenetic effects of nutrients and pheromones on gene expression (Kohl, 2013; Elekonich and Robinson, 2000).

See also: Age- and sex-dependent changes in levels of circulating brain-enriched microRNAs during normal aging

…changes in miRNA levels can reflect centrally regulated processes, including changes in hormone levels during menopause. Certain miRNAs and miRNA pairs correlated with age in the sex-stratified groups at different ages and should be investigated further as potentially promising biomarkers of brain aging.

miRNAs and miRNA pairs have been linked to energy-dependent healthy longevity in all living genera or to the virus-driven degradation of messenger RNA and all pathology via the Virus-mediated archaeal hecatomb in the deep seafloor

On the eve of the annual meeting of the Society for Neuroscience and during the week before the mid-term elections in the USA, it will be interesting to see if any serious scientists link what is known about the sense of smell in bacteria to our visual perception of energy and mass in the context of the space-time continuum before the Honduran Horde arrives to decimate the populations in the USA as did the European Hordes that killed millions of American Indians.

See: Olfaction Warps Visual Time Perception

In any case, on the day after the end of , which is post election day 2018 in the United States of America, the world of biologically uninformed theorists will change.

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Author: James Kohl

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